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Sunday, April 2, 2017

Recent advances in Parkinson's disease therapy


Abstract (as presented by the author of the scientific work):

"This article summarizes (1) the recent achievements to further improve symptomatic therapy of motor Parkinson's disease (PD) symptoms, (2) the still-few attempts to systematically search for symptomatic therapy of non-motor symptoms in PD, and (3) the advances in the development and clinical testing of compounds which promise to offer disease modification in already-manifest PD. However, prevention (that is, slowing or stopping PD in a prodromal stage) is still a dream and one reason for this is that we have no consensus on primary endpoints for clinical trials which reflect the progression in prodromal stages of PD, such as in rapid eye movement sleep behavior disorder (RBD) -a methodological challenge to be met in the future."


Covered topics (the letter size corresponds to the frequency of mentioning in the text):



Conclusions (as presented by the author of the scientific work):

"Neurologists have to accept that the majority of patients with PD, even at the very early stage of neurological diagnosis, actually present a late-stage phenotype of an alpha-synucleinopathy. Thus, PD has started at least 20 years before it manifests in the clinic with its motor symptoms. Neurologists will likely have to shift their clinical and diagnostic focus away from the dopaminergic system to symptoms related to different parts of the nervous system, such as the enteric system62, the brainstem with its autonomic control areas, the locus coeruleus57, or even the skin. If the dream of a disease-modifying therapy is to come true, neuroscience, drug development, and physician scientists face at least two challenges. First, drug development will target the aggregation and propagation of alpha-synuclein and of related mechanisms as well as mitochondrial dysfunction; second, a major effort has to be made to enhance the diagnostic methodology in order to identify a primary endpoint for clinical neuroprotective trials, not only in early motor PD but also in the prodromal stages of PD82–84. It has never been so exciting as today to work in the field of PD, and we should share this belief with the patients we diagnose, treat, and care for."


Full-text access of the referenced scientific work:

Oertel WH. Recent advances in treating Parkinson's disease. F1000Res. 2017 Mar
13;6:260. doi: 10.12688/f1000research.10100.1. eCollection 2017. Review. PubMed
PMID: 28357055; PubMed Central PMCID: PMC5357034.
https://f1000research.com/articles/6-260/v1


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https://about.me/Atanas_At


3 comments:

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  2. I am 56 year old who was diagnosed 4 years ago with Parkinson's. I had severe calf pain, muscle pain, slurred speech, frequent falls, loss of balance, difficulty in getting up from sitting position, i was having a problem accepting my diagnosis, even though I read every thing I could find to read. I was put on Sinemet 3 times daily but it doesn't seem to be helping. I also had difficulty writing now. Getting in bed, turning over. i have had good luck with the other meds like Mirapex, but I was extremely tired of it. I have also noticed cognitive decline, but that is also related to a now-removed brain tumor.As the disease progressed all medication stopped working, i was introduced to Health herbal clinic in Johannesburg who have successful herbal treatment to Parkinson's and other lungs diseases. I spoke to few people who used the treatment here in USA and they all gave a positive response, so i immediately purchased the P.D herbal remedy and commenced usage, i used the herbal supplement for only 8 weeks, all symptoms were unbelievably reversed, herbs are truly gift from God. contact this herbal clinic via their email healthherbalclinic @ gmail. com or visit www. healthherbalclinic. weebly. com

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  3. I am very happy to share this triumphant testimony on how i was cured on Parkinson, i never believed i was ever going to be cured from Parkinson. after being diagnosed, and i was penalized on how i will ever regain my self back back after suffering for 3 years of Parkinson . finally Dr Abumere cure gave me a reason to be happy again after searching online then i found out that Dr Abumere has save many lives of this disease. behold i was filled with Joy after writing to him on his email and visited his website and he responded to me that i shouldn’t be skeptical that my disease is very simple for him to handle. i hold on to his words then i attended to every of his instruction then i purchase the herbal medicine from him in south africa that is how my medicine was send to me via delivery service and he assured me after using his HERBAL MEDICINE in just 29 days i will be cured and i will come back and thank him, i went to check myself after 29 days although before the date i was really experiencing body release and my doc confirmed me Parkinson Negative.
    I really cant thank God enough for my life and i know once you contact this herbal doctor you shall be a testimony,contact his email:(abumereherbalcentre @ gmail . com) www.abumereherbalcentre . simplesite. com

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